[IMMUNE HEMOLYTIC ANEMIA]. In severe autoimmune hemolytic anemia nucleated red blood cells are commonly seen (arrowhead). Note the presence of numerous spherocytes (long arrow) and several reticulocytes (curved arrow). These patients generally show high serum LDH levels, low haptoglobin, and increased unconjugated bilirubin. Autoimmune hemolytic anemia may be seen in patients with certain autoimmune disorders and B-cell lymphoproliferative disorders. Other causes of immune hemolytic anemia include drug reaction to certain drugs and cold agglutinins.